Engineered phage endolysin is a potential solution for recurrent bacterial vaginosis

An engineered phage endolysin could offer a highly innovative and precise therapy for recurrent bacterial vaginosis, a disease for which no effective treatment option exists. Data on the novel endolysin targeting Gardnerella, the main pathogen in bacterial vaginosis, has now been published by the Vienna-based biotech company PhagoMed Biopharma GmbH. The data show that the novel drug candidate not only lyses any Gardnerella strain in vitro, but also fully dissolves the Gardnerella-dominated biofilm in vaginal samples of patients who had previously endured years of unsuccessful antibiotic treatment. Furthermore, due to the high specificity of…